The Greyer Lab at the Southern California University is home to Zigbar Miekbach, grad student extraordinaire. A computer genius, paranoid recluse, and chronic masturbator, Zigbar spends his days dissecting bodies for the university and his nights programming his supercomputer Harriet. Mike Zorillo lands a job as his assistant and the pair recognize their kindred spirits for innovation and mutual dislike of Dr. Martin "Rat Butt" Rabeau, PhD. Zigbar uses Harriet and his 3D body scanner to help Mike prove his theories.